Multivariate Mendelian randomization provides no evidence for causal associations among both psoriasis and psoriatic arthritis, and skin cancer

Background Some retrospective studies reported that psoriasis (PsO) and psoriatic arthritis (PsA) may have been associated with an elevated risk of skin cancer. The causal associations among them remain unclear. Objectives To evaluate the association both PsO PsA, Methods We performed large-scale two-sample Multivariate Mendelian randomization analyses to examine whether there is a relationship between cancer, encompassing basal cell carcinoma (BCC), cutaneous squamous (cSCC), melanoma (CM). Results Genetically predicted PsO, per log-odds ratio increase, showed no significant BCC, cSCC, CM. odds ratios (with corresponding 95% confidence intervals) for CM were 1.00 (0.99,1.01) (P Ivw = 0.990), 0.94(0.89, 1.00) 0.065), 0.99 (0.98, 1.01) 0.239), respectively. PsA decreased (1.00, 0.214) 0.477), Univariate analysis FinnGen database demonstrated did exhibit decrease 0.94(0.90,0.99) 0.016). However, this disappeared after other factors adjusted. Conclusions Our findings suggest genetic Further observational are required elucidate